Exhibit 99.1

JOINT FILING AGREEMENT

The undersigned agree that the statement on Schedule 13D, dated December 5, 2014, with respect to the Common Stock of Cocrystal Pharma, Inc. is, and any amendments hereto signed by each of the undersigned shall be, filed on behalf of each of us pursuant to and in accordance with the provisions of Rule 13(d) under the Securities Exchange Act of 1934, as amended.
 
December 5, 2014
 
/s/ Raymond F. Schinazi
Date   Raymond F. Schinazi
     
December 5, 2014
 
/s/ Phillip Frost, M.D.
Date   Phillip Frost, M.D.
     
 
 
December 5, 2014
 
Frost Gamma Investments Trust
 
By: /s/ Phillip Frost, M.D.
Date   Phillip Frost, M.D., Trustee
     
 
 
December 5, 2014
 
OPKO Health, Inc.
 
By: /s/ Phillip Frost, M.D.
Date   Phillip Frost, M.D., Chief Executive Officer
     
 
 
December 5, 2014
 
Bracrystal Pharmaceuticals, LLC
 
By: /s/ Vinzenz Ploerer
Date   Vinzenz Ploerer, President and Chief Executive Officer
     
December 5, 2014
 
/s/ Gary Wilcox
Date   Gary Wilcox
     
December 5, 2014
 
/s/ Roger Kornberg
Date   Roger Kornberg
     
December 5, 2014
 
/s/ Sam Lee
Date   Sam Lee
     
December 5, 2014
 
/s/ Steven D. Rubin
Date   Steven Rubin