| Item 1. | Security and Issuer |
| (a) | Title of Class of Securities:
Common Stock, par value $0.001 per share |
| (b) | Name of Issuer:
Cocrystal Pharma, Inc. |
| (c) | Address of Issuer's Principal Executive Offices:
19805 North Creek Parkway,, Bothell,
WASHINGTON
, 98011. |
Item 1 Comment:
This Amendment No. 8 on Schedule 13D/A (this "Amendment") is being filed with the Securities and Exchange Commission (the "SEC") on behalf of the Reporting Persons (as defined below) and relates to the common stock, par value $0.001 per share, of Cocrystal Pharma, Inc. (the "Issuer"). This Amendment is being filed as a result of a change in the Reporting Person's beneficial ownership of the common stock, and in the total number of shares of the Issuer's issued and outstanding common stock and, where so stated, amends and supplements Amendment No. 7 to the Schedule 13D and all previous filings on Schedule 13D. |
| Item 2. | Identity and Background |
|
| (a) | This Amendment is filed on behalf of Phillip Frost, M.D. and Frost Gamma Investments Trust (together, the "Reporting Persons"). |
| (b) | The principal business address of the Reporting Persons is 4400 Biscayne Boulevard, Miami, Florida 33137. |
| (d) | During the last five years, none of the Reporting Persons have been convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors). |
| (e) | During the last five years, none of the Reporting Persons (or their directors, officers, or controllers, if applicable) have been a party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding were or are subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violations with respect to such laws. |
| (f) | Dr. Frost is a citizen of the United States of America. Frost Gamma Investments Trust was organized in the State of Florida. |
| Item 3. | Source and Amount of Funds or Other Consideration |
| | On August 3, 2026, the Reporting Persons purchased 75,000 shares of the Issuer's common stock in the open market at $0.9412 per share. On August 5, 2026, the Reporting Persons purchased an additional 10,000 shares of the Issuer's common stock in the open market at $0.9816 per share. |
| Item 4. | Purpose of Transaction |
| | The Reporting Persons acquired the shares of common stock for investment purposes.
These securities are held by Frost Gamma Investments Trust, of which Phillip Frost, MD is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is the sole shareholder of Frost-Nevada Corporation. Dr. Frost disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that Dr. Frost is the beneficial owner of these securities for purposes of Section 16 of the Securities Exchange Act of 1934 or for any other purpose. |
| Item 5. | Interest in Securities of the Issuer |
| (a) | The beneficial ownership percentages disclosed below are based on 19,263,200 shares of common stock outstanding as of August 3, 2026, 51,417 shares of common stock issuable upon exercise of options and 719,426 shares of common stock issuable upon exercise of warrants, both within 60 days.
Dr. Frost is the beneficial owner of 2,784,719 shares of common stock representing 13.9% of the shares outstanding of the Issuer, including (i) 1,993,551 shares of common stock held by Frost Gamma Investments Trust, (ii) 20,325 shares of the Issuer's common stock held by the Reporting Person, (iii) 51,417 shares of common stock issuable upon exercise of vested options and (iv) 719,426 shares of common stock issuable upon exercise of warrants. Dr. Frost is the trustee of Frost Gamma Investments Trust. Frost Gamma Limited Partnership is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma Limited Partnership. Dr. Frost is the sole shareholder of Frost-Nevada Corporation, which is the sole shareholder of Frost Gamma, Inc., the general partner of Frost Gamma Limited Partnership. As a result of the foregoing, Dr. Frost may be deemed the beneficial owner of the shares of common stock held by Frost Gamma Investments Trust. Dr. Frost disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust except to the extent of any pecuniary interest therein.
Dr. Frost has sole dispositive power with respect to 51,417 shares of common stock issuable upon exercise of vested options. |
| (b) | The Reporting Persons have voting and dispositive power over the Issuer's securities as described above in Item 5(a). |
| (c) | Except as described in this Schedule 13D under Item 3 above, the Reporting Persons did not engage in any transactions in shares of the Company's common stock during the past 60 days. |
| (d) | Not Applicable. |
| (e) | Not Applicable. |
| Item 6. | Contracts, Arrangements, Understandings or Relationships With Respect to Securities of the Issuer |
| | Not Applicable. |
| Item 7. | Material to be Filed as Exhibits. |
| | None. |
